John T O'Brien Selected Research

Corticobasal Degeneration

4/2024	Differential Synaptic Loss in β-Amyloid Positive Versus β-Amyloid Negative Corticobasal Syndrome.
1/2023	Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [11 C]UCB-J Positron Emission Tomography Study.
1/2022	Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study.
1/2021	In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

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John T O'Brien Research Topics

Disease

109	Dementia (Dementias) 04/2024 - 07/2002
58	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 03/2002
55	Cognitive Dysfunction 10/2023 - 03/2002
31	Parkinson Disease (Parkinson's Disease) 09/2023 - 11/2004
24	Atrophy 01/2024 - 06/2004
17	Lewy Body Disease (Lewy Body Dementia) 01/2023 - 07/2005
13	Inflammation (Inflammations) 04/2024 - 01/2005
12	Neuroinflammatory Diseases 09/2023 - 12/2015
10	Hallucinations (Hallucination) 10/2023 - 07/2005
8	Stroke (Strokes) 01/2023 - 01/2004
8	Frontotemporal Dementia (Semantic Dementia) 01/2023 - 08/2011
7	Disease Progression 01/2022 - 01/2017
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2024 - 01/2018
6	Tauopathies 01/2022 - 12/2016
6	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 01/2017
5	Pathologic Processes 01/2023 - 06/2004
4	Corticobasal Degeneration 04/2024 - 01/2021
4	Vascular Diseases (Vascular Disease) 05/2020 - 04/2004
4	Parkinsonian Disorders (Parkinsonism) 10/2018 - 10/2007
3	Neurobehavioral Manifestations 01/2017 - 08/2011
3	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2017 - 04/2004
2	Neurocognitive Disorders (Clerambault Syndrome) 03/2024 - 01/2023
2	Schizophrenia (Dementia Praecox) 02/2024 - 03/2004
2	Cerebral Small Vessel Diseases 01/2023 - 01/2018
2	Cerebral Cortical Thinning 01/2023 - 10/2015
2	Lacunar Stroke 01/2023 - 09/2022
2	Genetic Predisposition to Disease (Genetic Predisposition) 10/2022 - 01/2018
2	Hypoxia (Hypoxemia) 01/2019 - 06/2006
2	Synucleinopathies 01/2019 - 01/2003
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 10/2018 - 12/2016
2	Encephalitis (Encephalitis, Rasmussen) 01/2017 - 10/2011
2	Movement Disorders (Movement Disorder) 08/2014 - 07/2014
2	Pain (Aches) 10/2012 - 02/2011
2	Hypertension (High Blood Pressure) 01/2011 - 08/2010
2	Memory Disorders (Memory Loss) 11/2007 - 11/2004
1	Fatigue 04/2024
1	Nervous System Diseases (Neurological Disorders) 02/2024

Drug/Important Bio-Agent (IBA)

45	Biomarkers (Surrogate Marker)IBA 04/2024 - 10/2011
34	Amyloid (Amyloid Fibrils)IBA 04/2024 - 10/2011
18	Cholinergic Agents (Cholinergics)IBA 10/2023 - 03/2005
12	LigandsIBA 04/2024 - 03/2005
11	Proteins (Proteins, Gene)FDA Link 02/2024 - 06/2006
11	2- carbomethoxy- 8- (3- fluoropropyl)- 3- (4- iodophenyl)tropaneIBA 01/2023 - 06/2004
11	Cholinesterase Inhibitors (Anticholinesterases)IBA 11/2022 - 04/2003
7	(R)- (11C)1- (2- chlorophenyl)- N- methyl- N- (1- methylpropyl)- 3- isoquinolinecarboxamideIBA 09/2023 - 01/2017
7	CytokinesIBA 09/2023 - 01/2005
7	Apolipoproteins E (ApoE)IBA 01/2023 - 11/2004
7	SynucleinsIBA 01/2022 - 10/2011
7	Donepezil (Aricept)FDA LinkGeneric 01/2020 - 01/2007
7	Antipsychotic Agents (Antipsychotics)IBA 01/2019 - 01/2004
6	ApolipoproteinsIBA 01/2024 - 12/2011
5	3-Iodobenzylguanidine (Iobenguane)IBA 01/2023 - 07/2017
4	C-Reactive ProteinIBA 04/2024 - 12/2018
4	Pemetrexed (MTA)FDA Link 01/2016 - 11/2007
4	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 09/2015 - 03/2005
4	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2014 - 06/2004
4	Hydrocortisone (Cortisol)FDA LinkGeneric 02/2010 - 03/2002
3	Amyloid beta-PeptidesIBA 01/2023 - 09/2015
3	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2023 - 10/2011
3	Apolipoprotein E4IBA 10/2022 - 01/2021
3	Indicators and Reagents (Reagents)IBA 01/2022 - 01/2004
3	alpha-SynucleinIBA 01/2020 - 01/2003
3	ioflupaneIBA 01/2018 - 07/2014
3	Memantine (Namenda)FDA Link 12/2017 - 08/2011
3	5-iodo-3-(2-azetidinylmethoxy)pyridineIBA 11/2016 - 04/2008
3	N 30IBA 01/2016 - 12/2014
3	HomocysteineIBA 12/2011 - 08/2010
2	Minocycline (Cyclops)FDA LinkGeneric 04/2024 - 09/2022
2	tau Proteins (tau Protein)IBA 09/2023 - 12/2020
2	A-factor (Streptomyces)IBA 01/2023 - 01/2015
2	Messenger RNA (mRNA)IBA 01/2023 - 01/2022
2	Dopamine (Intropin)FDA LinkGeneric 01/2023 - 03/2009
2	IodineIBA 01/2023 - 06/2004
2	CholesterolIBA 08/2022 - 04/2004
2	FHDIBA 08/2022 - 01/2020
2	Trazodone (Trittico)FDA LinkGeneric 02/2022 - 01/2022
2	1- ((3- (methylpyridin- 4- yl)methyl)- 4- (3,4,5- trifluorophenyl)pyrrolidin- 2- oneIBA 01/2022 - 01/2020
2	Fibrinogen (Factor I)FDA Link 01/2021 - 01/2019
2	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2021 - 01/2018
2	PK 11195 (PK11195)IBA 12/2020 - 01/2020
2	Interleukin-6 (Interleukin 6)IBA 01/2019 - 02/2016
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2017 - 08/2011
2	Rivastigmine (Exelon)FDA LinkGeneric 01/2017 - 08/2011
2	Galantamine (Galanthamine)FDA LinkGeneric 01/2017 - 08/2011
2	Vitamin E FDA LinkGeneric 01/2017 - 08/2011
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2017 - 08/2011
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 12/2014
2	Antidepressive Agents (Antidepressants)IBA 02/2015 - 10/2007
2	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 12/2014 - 06/2014
2	Levodopa (L Dopa)FDA LinkGeneric 10/2014 - 03/2009
2	Immunoglobulins (Immunoglobulin)IBA 05/2012 - 01/2012
2	Cell Adhesion MoleculesIBA 10/2007 - 03/2004
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 03/2004 - 01/2003
1	Cyclophilins (Cyclophilin)IBA 02/2024
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 02/2024

Therapy/Procedure

12	Therapeutics 09/2023 - 04/2003
3	Drug Therapy (Chemotherapy) 12/2017 - 08/2011
2	Ambulatory Care (Outpatient Care) 01/2023 - 01/2017
2	Activities of Daily Living (ADL) 06/2020 - 12/2013
2	Home Nursing (Nursing, Home) 10/2012 - 02/2011